Plasma Proteome-Wide Mendelian Randomization with Multi-Layer Triangulation Identifies Druggable Targets for Uterine Leiomyoma

Background

Uterine leiomyoma (fibroids) is the most common benign tumor in women and the leading indication for hysterectomy, yet medical therapy remains limited and largely hormonal. Whether circulating proteins causally influence fibroid risk, and could therefore be repurposed as drug targets, has not been examined proteome-wide.

Methods