CD73-Overexpressing ADSCs Promote Neurogenic Bladder Repair via A2A-JAK1/STAT3-Mediated Modulation of Inflammation and Macrophage Polarization

Background

Neurogenic bladder (NB) is characterized by chronic inflammation and bladder tissue injury, and current treatments fail to restore the inflammatory microenvironment or tissue integrity. Although adipose-derived stem cell (ADSC) therapy shows regenerative potential, its efficacy is limited by inflammation; whether CD73 overexpression enhances ADSC therapeutic effects in NB remains unclear.