High-Dose Inhaled Colistin-Aminoglycoside Combination Therapy in Critically Ill Patients With Multidrug-Resistant Pseudomonas aeruginosa Hospital/Ventilator-Associated Pneumonia: A Case Report and Literature Review

Background

Multidrug-resistant Pseudomonas aeruginosa (MDR PA) ventilator-associated pneumonia (VAP) and hospital-associated pneumonia (HAP) are associated with high morbidity and limited therapeutic options. Intravenous antibiotics often achieve inadequate pulmonary concentrations. Aerosolized delivery permits high local drug exposure, but data on combined inhaled polymyxin-aminoglycoside therapy remain limited.