Evaluation for antidiabetic activities of flavonoids

This study aims to evaluate the effects on antidiabetic activities of petroleum ether extract (SMPE), ethyl acetate extract (SMAE), and flavonoids isolated from Syzygium malaccense. The results discovered compounds 2, 5, 7, and 9 exhibited weak inhibitory activity against α-glucosidase with percent inhibition rate of 2.74±0.26 ~ 10.20±0.33 at 1.00×10 -6 mol/L and 9 showed weak promotion on glucose consumption in HepG2 cells with consumption rate of 4.03±2.70 % at 1.00×10 -6 mol/L. All compounds were firstly tested their HepG2 cells glucose consumption activities, and 6 and 8 ~ 10 were the first report on their α-glucosidase inhibitory effect. This research provided new evidences for antihyperglycemic activity of S. malaccense.