Network Pharmacology-Assisted Multi-Omics Analysis of Gut Microbiota–Host Metabolic Remodeling and Hepatic HPD/GSTM3-Associated Redox Responses Following Shanqijing Treatment in STZ-Induced Diabetic Mice

Background/Objectives: Shanqijing (SQJ) is a multibotanical aqueous extract prepared from an equal-ratio blend of Astragali Radix, Dioscoreae Rhizoma, Corni Fructus, Polygonati Rhizoma, and Polygonati Odorati Rhizoma. This study investigated the pharmacological effects and systems-level response pattern of SQJ in streptozotocin-induced diabetic mice.

Methods

The study integrated chemical profiling, multi-omics analyses, and network pharmacology-assisted analysis with targeted assessment of hepatic HPD/GSTM3 expression and oxidative stress.