Gastroprotective Effects of a Polyherbal Formulation (HF33) in Experimental Gastric Ulcer Models and Its Acute Oral Toxicity Evaluation

Background/Objectives: HF33 is a polyherbal formulation developed from Thai folk medicinal knowledge for the management of dyspepsia and gastric ulcer-like symptoms. Its gastroprotective activity and underlying mechanisms have not been systematically investigated. This study aimed to characterize the HF33 formulation and evaluate the gastroprotective activity, possible mechanisms of action, and acute oral toxicity of its ethanolic extract.