Nutrients
Association of Frailty Status with Semi-Targeted Metabolomics and Untargeted Proteomics in Older Adults Referred for Physical Therapy in a Geriatric Clinic
Por Dakota J. Batchek, David H. Lynch, Laura Herring y 6 más.
Contenido en inglés
Resumen
Background
Older adults are vulnerable to frailty, but the biological mechanisms are unclear. Metabolomics and proteomics may help characterize the biological basis of frailty that can be used to target future interventions.
Methods
This study is a cross-sectional analysis of baseline anthropometric, metabolomic, and proteomic data collected from older adults enrolled in a 12-week prospective physical therapy intervention. Frailty was classified using a modified Cumulative Deficit Index (CDI; 37 variables) and the Fried Frailty Index (5 variables). Gait speed, grip strength, and patient-reported outcome surveys were administered. Baseline plasma was analyzed via semi-targeted metabolomics (capillary electrophoresis-mass spectrometry) and untargeted proteomics (LC-MS/MS) using the CDI-defined frailty classification.