Monkeypox Virus in Healthcare Settings, Sierra Leone, June 2025

During the 2025 mpox outbreak in Sierra Leone, we assessed environmental contamination in 2 hospitals. Of 89 surfaces sampled, 6 (6.7%) surface samples, primarily from doors, were PCR-positive for monkeypox virus. Our findings highlight monkeypox virus surface contamination in healthcare settings and help prioritize infection prevention and control targets in resource-limited settings.