International Journal of COPD
Baseline Neutrophil-to-Lymphocyte Ratio and Longitudinal Lung Function Decline in Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study
Por Hanyu Xue, Zexiu Wang, Lihua Luo y 4 más.
Contenido en inglés
Resumen
Background
Systemic inflammation may contribute to heterogeneous lung function trajectories in chronic obstructive pulmonary disease (COPD), but evidence linking the neutrophil-to-lymphocyte ratio (NLR) to longitudinal forced expiratory volume in one second (FEV1) change is limited.
Methods
We analyzed repeated spirometry from a single-center retrospective cohort. Eligibility required clinically stable chronic obstructive pulmonary disease, baseline blood counts, at least two qualified spirometry assessments, and at least 12 months of recorded follow-up. Linear mixed-effects models estimated the association between baseline log2-transformed neutrophil-to-lymphocyte ratio and annual forced expiratory volume in one second (FEV1) change. Sequential models added demographic and exposure variables, then baseline disease severity. Post hoc analyses examined common visit windows and sensitivity to covariate selection.