Investigative Ophthalmology & Visual Science
Multimodal Retinal Structural and Functional Tests Identify Local and Layer-Related Alterations in Early Type 2 Diabetes
Por Bismark Owusu-Afriyie, Christopher S. Wu, Rachana Kafle y 5 más.
Contenido en inglés
Resumen
Purpose
To use a multimodal approach to provide deeper insights into subclinical, layer-related, and localized retinal structural and functional deficits associated with prediabetes (PreDM) and early type 2 diabetes (T2DM).
Methods
Twenty controls, 13 PreDM, and 15 T2DM age-matched (45.58 ± 9.40 years) groups participated. Color perimetry was performed at four locations 3° from fixation, using 0.5° circular red, green, blue, and yellow stimuli. Multifocal electroretinograms (mfERGs) were recorded (103 hexagons), and implicit times (ITs) and amplitudes were averaged and analyzed in ring 2, approximately corresponding to the perimetric testing. Then, 20° optical coherence tomography (OCT) and 10° OCT angiography (OCTA) images were acquired. Perfusion density (PD; all plexuses), retinal layers, and choroidal thicknesses were analyzed (central 2 mm).