Vasostrict

Vasostrict® is indicated to increase blood pressure in adults with vasodilatory shock (e.g., post-cardiotomy or sepsis) who remain hypotensive despite fluids and catecholamines.

Vasostrict® is contraindicated in patients with known allergy or hypersensitivity to 8-L-arginine vasopressin or chlorobutanol.

5.1Worsening Cardiac Function Use

in patients with impaired cardiac response may worsen cardiac output.

7.1Catecholamines Use

with catecholamines is expected to result in an additive effect on mean arterial blood pressure and other hemodynamic parameters.

7.2Indomethacin Use

with indomethacin may prolong the effect of Vasostrict® on cardiac index and systemic vascular resistance [see Clinical Pharmacology ( 12- 12.3)].

7.3Ganglionic Blocking Agents Use

with ganglionic blocking agents may increase the effect of Vasostrict® on mean arterial blood pressure [see Clinical Pharmacology ( 12- 12.3)].

7.4Furosemide Use

with furosemide increases the effect of Vasostrict® on osmolar clearance and urine flow [see Clinical Pharmacology ( 12- 12.3)].

7.5Drugs Suspected of Causing SIADH Use

with drugs suspected of causing SIADH (e.g., SSRIs, tricyclic antidepressants, haloperidol, chlorpropamide, enalapril, methyldopa, pentamidine, vincristine, cyclophosphamide, ifosfamide, felbamate) may increase the pressor effect in addition to the antidiuretic effect of Vasostrict®.