Sodium Chloride 0.45% in Plastic Container

Intravenous solutions containing sodium chloride are indicated for parenteral replenishment of fluid and sodium chloride as required by the clinical condition of the patient.

None known.

0.45% Sodium chloride injection should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention. The intravenous administration of 0.45% Sodium chloride injection can cause fluid and/or solute overloading resulting in dilution of serum electrolyte concentrations, overhydration, congested states or pulmonary edema.

The risk of dilutive states is inversely proportional to the electrolyte concentration of the injections. The risk of solute overload causing congested states with peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of the injections. In patients with diminished renal function, administration of 0.45% Sodium chloride injection may result in sodium retention.

Drug Interactions Caution must be exercised in the administration of 0.45% Sodium chloride injection to patients receiving corticosteroids or corticotropin.

Pregnancy Teratogenic Effects Pregnancy Category C Animal reproduction studies have not been conducted with 0.45% Sodium chloride injection. It is also not known whether 0.45% Sodium chloride injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. 0.45% Sodium chloride injection should be given to a pregnant woman only if clearly needed.