Indications
INFUVITE PEDIATRIC is a combination of vitamins indicated for the prevention of vitamin deficiency in pediatric patients up to 11 years of age receiving parenteral nutrition. The physician should not await the development of clinical signs of vitamin deficiency before initiating vitamin therapy. INFUVITE PEDIATRIC is a combination of vitamins indicated for the prevention of vitamin deficiency in pediatric patients up to 11 years of age receiving parenteral nutrition ( 1 )
Contraindications
INFUVITE PEDIATRIC is contraindicated in patients who have:
- An existing hypervitaminosis, or
- A history of hypersensitivity to any vitamins or excipients contained in this formulation.
- Hypersensitivity to any of vitamins or excipients ( 4 )
- Existing hypervitaminosis ( 4 )
Warnings and precautions
- Risk of Aluminum Toxicity : For at risk patients (renal failure or those with prolonged therapy), consider periodic monitoring of aluminum levels ( 5.1 )
- Allergic Reactions : To thiamine may occur ( 5.2 )
- Hypervitaminosis A : Patients with renal failure or liver disease may be at higher risk ( 5.3 )
- Decreased Anticoagulant Effect of Warfarin : Monitor INR ( 5.4 , 7.1 )
- Interferes with Megaloblastic Anemia Diagnosis : Avoid during testing for this disorder ( 5.5 )
- Risk of Vitamin Deficiencies or Excesses : Monitor blood vitamin concentrations ( 5.6 )
- False Negative Urine Glucose Tests : Due to vitamin C ( 5.7 )
- Risk of Vitamin E Toxicity : Additional oral and parenteral vitamin E may result in elevated vitamin E blood concentrations in infants ( 5.8 )
- Low Vitamin A Levels : Monitor vitamin A levels ( 5.9 )
- Risk of E-Ferol Syndrome : Due to polysorbates ( 5.10 )
5.1Aluminum Toxicity
INFUVITE PEDIATRIC contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration in pediatric patients with renal impairment. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solution, which contain aluminum. Research indicates that patients with impaired kidney function, including premature neonates who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity.