Immphentiv

Phenylephrine Hydrochloride is an alpha-1 adrenergic receptor agonist indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation, in such settings as septic shock or anesthesia. Phenylephrine Hydrochloride is an alpha-1 adrenergic receptor agonist indicated for increasing blood pressure in adults with clinically important hypotension resulting primarily from vasodilation, in such settings as septic shock or anesthesia.

The use of phenylephrine hydrochloride is contraindicated in patients with: Hypersensitivity to it or any of its components Hypersensitivity to it or any of its components ( 4 )

Severe bradycardia and decreased cardiac output: ( 5.2 ) Extravasation: during intravenous administration may cause necrosis or sloughing of tissue ( 5.4 ) Concomitant use with oxytocic drugs: pressor effect of sympathomimetic pressor amines is potentiated ( 5.5 ) Allergic-type reactions: Sulfite ( 5.6 )

5.1Exacerbation of Angina, Heart Failure, or Pulmonary Arterial Hypertension Because

of its pressor effects, phenylephrine hydrochloride can precipitate angina in patients with severe arteriosclerosis or history of angina, exacerbate underlying heart failure, and increase pulmonary arterial pressure.

5.2Bradycardia

Phenylephrine hydrochloride can cause severe bradycardia and decreased cardiac output.

5.3Risk in Patients with Autonomic Dysfunction

The pressor response to adrenergic drugs, including phenylephrine, can be increased in patients with autonomic dysfunction, as may occur with spinal cord injuries.