Furosemide

Furosemide Injection is a loop diuretic indicated for:

• The treatment of edema associated with heart failure, cirrhosis of the liver, and renal disease ( 1.1 )
• Acute pulmonary edema as adjunctive therapy ( 1.2 )

1.1Edema Furosemide

Injection is indicated in adults and pediatric patients for the treatment of edema associated with heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome.

1.2Acute Pulmonary Edema Furosemide

Injection is indicated as adjunctive therapy in acute pulmonary edema.

Furosemide is contraindicated in patients with anuria and in patients with a history of hypersensitivity to furosemide.

In patients with hepatic cirrhosis and ascites, furosemide therapy is best initiated in the hospital. In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved. Sudden alterations of fluid and electrolyte balance in patients with cirrhosis may precipitate hepatic coma; therefore, strict observation is necessary during the period of diuresis. Supplemental potassium chloride and, if required, an aldosterone antagonist are helpful in preventing hypokalemia and metabolic alkalosis.

If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, furosemide should be discontinued. Cases of tinnitus and reversible or irreversible hearing impairment and deafness have been reported. Reports usually indicate that furosemide ototoxicity is associated with rapid injection, severe renal impairment, the use of higher than recommended doses, hypoproteinemia or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs.