Dextrose 2.5% and Sodium Chloride 0.45% in Plastic Container

2.5% Dextrose and 0.45% Sodium Chloride Injection is indicated as a source of water, electrolytes and calories. 2.5% Dextrose and 0.45% Sodium Chloride Injection is indicated as a source of water, electrolytes and calories. ( 1 )

2.5% Dextrose and 0.45% Sodium Chloride Injection is contraindicated in patients with: known hypersensitivity to dextrose and/or sodium chloride [see Warnings and Precautions 5.1 )] clinically significant hyperglycemia [see Warnings and Precautions ( 5.2 )] Known hypersensitivity to dextrose, or sodium chloride ( 4 , 5.1 ) Clinically significant hyperglycemia ( 4 , 5.2 )

Hypersensitivity Reactions: Monitor for signs and symptoms and discontinue infusion if reactions occur. ( 5.1 ) Hyperglycemia or Hyperosmolar Hyper glycemic State: Monitor blood glucose and administer insulin as needed. ( 5.2 , 8.4 ) Hyponatremia, Hypokalemia, Hypernatremia and Hyperchloremia: Avoid in patients with or at risk for hypo-/hypernatremia and hypokalemia. If use cannot be avoided, monitor serum sodium and potassium concentrations.

( 5.3 , 5.4 , 5.5 , 8.4 ) Fluid Overload: Avoid in patients with or at risk for fluid and/or solute overloading. If use cannot be avoided, monitor daily fluid balance and electrolyte, concentrations and acid-base balance, as needed and especially during prolonged use. ( 5.6 ) Refeeding Syndrome: Monitor severely undernourished patients and slowly increase nutrient intake. ( 5.7 )

5.1Hypersensitivity Reactions Hypersensitivity

and infusion reactions, including anaphylaxis, have been reported with 2.5% Dextrose and 0.45% Sodium Chloride Injection [see Adverse Reactions ( 6 )] . Stop the infusion immediately if signs or symptoms of a hypersensitivity or infusion reaction develops [see Contraindications ( 4 )] . Appropriate therapeutic countermeasures must be instituted as clinically indicated.