Desonide

Desonide ointment, 0.05% is a low potency corticosteroids indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses. It should not be used for longer than two weeks unless directed by a physician.

Desonide ointment, 0.05% is contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

Pregnancy Teratogenic Effects Corticosteroids have been shown to be teratogenic in laboratory animals when administered systemically at relatively low dosage levels. Some corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. Animal reproductive studies have not been conducted with desonide ointment, 0.05%. It is also not known whether desonide ointment, 0.05% can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.

There are no adequate and well-controlled studies in pregnant women. Desonide ointment, 0.05% should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

In controlled clinical trials, the total incidence of adverse reactions associated with the use of desonide ointment, 0.05% was approximately 6%. The adverse reactions for desonide ointment, 0.05% were erythema, induration, pruritus, irritation, oiliness, and peripheral edema. The following additional local adverse reactions have been reported infrequently with topical corticosteroids, and they may occur more frequently with the use of occlusive dressings and higher potency corticosteroids.

These reactions are listed in approximate decreasing order of occurrence: dryness, folliculitis, acneiform eruptions, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, miliaria, burning and hypopigmentation.