Clinimix 4.25/5 Sulfite Free in Dextrose 5% in Plastic Container

CLINIMIX is indicated as a source of calories and protein for patients requiring parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated. CLINIMIX may be used to treat negative nitrogen balance in patients. CLINIMIX is indicated as a source of calories and protein for patients requiring parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.

CLINIMIX may be used to treat negative nitrogen balance in patients. ( 1 )

The use of CLINIMIX is contraindicated in:

• Patients with known hypersensitivity to one or more amino acids or dextrose [see Warnings and Precautions (5.2) ] .
• Patients with inborn errors of amino acid metabolism due to risk of severe metabolic and neurologic complications.
• Patients with pulmonary edema or acidosis due to low cardiac output.
• Known hypersensitivity to one or more amino acids or dextrose. ( 4)
• Inborn errors of amino acid metabolism. ( 4 )
• Patients with pulmonary edema or acidosis due to low cardiac output. ( 4 )

• Pulmonary Embolism due to Pulmonary Vascular Precipitates : if signs of pulmonary distress occur, stop the infusion and initiate a medical evaluation. ( 5.1 )
• Hypersensitivity Reactions : monitor for signs and symptoms and discontinue infusion if reactions occur. ( 5.2 )
• Risk of Infections, Refeeding Complications, and Hyperglycemia or Hyperosmolar Hyperglycemic State : monitor for signs and symptoms; monitor laboratory parameters. ( 5.3 , 5.4 , 5.5 )
• Vein Damage and Thrombosis : solutions with osmolarity of ≥ 900 mOsm/L must be infused through a central catheter. ( 2.2 , 5.6 )
• Hepatobiliary Disorders : monitor liver function parameters and ammonia levels. ( 5.7 )
• Aluminum Toxicity : increased risk in patients with impaired kidney function, including preterm infants. ( 5.8 , 8.4 )