FDA

Anectine

Approved 20 Aug 1952InjectionInjectable

The FDA lists this product in 4 strengths and forms.

Indications

ANECTINE is indicated in adults and pediatric patients:

as an adjunct to general anesthesia
to facilitate tracheal intubation
to provide skeletal muscle relaxation during surgery or mechanical ventilation. ANECTINE is a depolarizing neuromuscular blocker indicated in adults and pediatric patients:
as an adjunct to general anesthesia ( 1 )
to facilitate tracheal intubation ( 1 )
to provide skeletal muscle relaxation during surgery or mechanical ventilation ( 1 ).

ANECTINE is contraindicated in patients with:

Known or suspected genetic susceptibility to malignant hyperthermia [see WARNINGS, Malignant Hyperthermia ( 5.5 ), CLINICAL PHARMACOLOGY, Pharmacogenomics ( 12.5 )]
Skeletal muscle myopathies [see WARNINGS, Ventricular Dysrhythmias, Cardiac Arrest, and Death From Hyperkalemic Rhabdomyolysis in Pediatric Patients ( 5.1 )]
Known hypersensitivity to succinylcholine [see Warnings and Precautions (5.2) ] .
After the acute phase of injury following major burns, multiple trauma, extensive denervation of the skeletal muscle, or upper neuron injury because succinylcholine administered to such individuals may result in severe hyperkalemia, which may result in cardiac arrest [see Warnings and Precautions (5.4) ] .
Skeletal muscle myopathies ( 4 )
Known hypersensitivity to succinylcholine ( 4 )
After the acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury ( 4 )
Known or suspected genetic susceptibility to malignant hyperthermia ( 4 )

Anaphylaxis : Severe anaphylactic reactions to neuromuscular blocking agents, including succinylcholine, have been reported. Some cases have been life-threatening and fatal. Take necessary precautions, such as the immediate availability of appropriate emergency treatment ( 5.2 ).
Risk of Death due to Medication Errors : Unintended administration of ANECTINE results in paralysis, which may lead to respiratory arrest and death. Confirm proper selection of intended product and avoid confusion with other injectable solutions that are present in critical care and other clinical settings ( 5.3 ).
Hyperkalemia : ANECTINE may induce serious cardiac arrhythmias or cardiac arrest due to hyperkalemia ( 5.4 ).

Indications

ANECTINE is indicated in adults and pediatric patients:

as an adjunct to general anesthesia
to facilitate tracheal intubation
to provide skeletal muscle relaxation during surgery or mechanical ventilation. ANECTINE is a depolarizing neuromuscular blocker indicated in adults and pediatric patients:
as an adjunct to general anesthesia ( 1 )
to facilitate tracheal intubation ( 1 )
to provide skeletal muscle relaxation during surgery or mechanical ventilation ( 1 ).

Contraindications

ANECTINE is contraindicated in patients with:

Known or suspected genetic susceptibility to malignant hyperthermia [see WARNINGS, Malignant Hyperthermia ( 5.5 ), CLINICAL PHARMACOLOGY, Pharmacogenomics ( 12.5 )]
Skeletal muscle myopathies [see WARNINGS, Ventricular Dysrhythmias, Cardiac Arrest, and Death From Hyperkalemic Rhabdomyolysis in Pediatric Patients ( 5.1 )]
Known hypersensitivity to succinylcholine [see Warnings and Precautions (5.2) ] .
After the acute phase of injury following major burns, multiple trauma, extensive denervation of the skeletal muscle, or upper neuron injury because succinylcholine administered to such individuals may result in severe hyperkalemia, which may result in cardiac arrest [see Warnings and Precautions (5.4) ] .
Skeletal muscle myopathies ( 4 )
Known hypersensitivity to succinylcholine ( 4 )
After the acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury ( 4 )
Known or suspected genetic susceptibility to malignant hyperthermia ( 4 )

Warnings and precautions

Anaphylaxis : Severe anaphylactic reactions to neuromuscular blocking agents, including succinylcholine, have been reported. Some cases have been life-threatening and fatal. Take necessary precautions, such as the immediate availability of appropriate emergency treatment ( 5.2 ).
Risk of Death due to Medication Errors : Unintended administration of ANECTINE results in paralysis, which may lead to respiratory arrest and death. Confirm proper selection of intended product and avoid confusion with other injectable solutions that are present in critical care and other clinical settings ( 5.3 ).
Hyperkalemia : ANECTINE may induce serious cardiac arrhythmias or cardiac arrest due to hyperkalemia ( 5.4 ).