PloS one
HLA-driven variability in human cytomegalovirus immune recognition: Epitope predictions from a kidney transplant Cohort
By Moreno Rosado MD, Chavez-Arias T, Marín-Sánchez O and 5 others.
Abstract
Background
Human cytomegalovirus (HCMV) infection causes life-threatening complications in transplant recipients. Despite a seroprevalence exceeding 90% in Peru, the influence of HLA diversity on HCMV immune recognition remains unexplored in the South American region. We aimed to characterize the HLA allele distribution in a Peruvian cohort and evaluate its impact on the predicted HCMV antigen-presentation landscape.