Frontiers in immunology
Fresh ginseng-derived vesicle-like nanoparticles protect against intestinal barrier injury in inflammatory bowel disease via the miR-29a-5p/TLR4 axis
By Tang X, Ren Y, He M and 5 others.
Abstract
Background
Inflammatory bowel disease (IBD) remains therapeutically challenging, and disruption of the intestinal epithelial barrier constitutes a key pathogenic event. Ginseng-derived vesicle-like nanoparticles (GDNPs) protect against intestinal barrier injury in IBD; however, the effects of ginseng processing on nanoparticle characteristics and biological activity remain insufficiently understood.
