Circulating arginine-nitric oxide pathway metabolites and nitrated fatty acids in relation to pathological features of colorectal cancer

Introduction

Colorectal cancer (CRC) is associated with metabolic and inflammatory disturbances, including alterations in the arginine-nitric oxide (NO) pathway. This study assessed serum metabolites related to the arginine-NO-nitrated fatty acid (NO₂-FA) axis in patients with CRC and examined their associations with tumor stage and pathological features.