Cancer reports
Peripheral Lymphocyte Subsets Predict Efficacy and Overall Survival in Gastric Cancer Patients Receiving Preoperative Chemotherapy: A Retrospective Cohort Study
By Xue Z, Liu D, Sun Z and 6 others.
Abstract
Background
Pathologic complete response (pCR), which reflects the local immune status and preoperative chemotherapy efficacy, has garnered significant attention in gastric cancer research. However, the predictive value of peripheral lymphocyte subsets for pCR in gastric cancer patients receiving preoperative chemotherapy remains unclear.
Aims
This study aims to assess the correlation between preoperative peripheral lymphocyte subsets and pCR in gastric cancer patients. Methods and results: In this retrospective study, gastric cancer patients who underwent curative gastrectomy following preoperative chemotherapy were included. Cytokines and peripheral lymphocytes were measured using flow cytometry. Clinicopathological characteristics, peripheral lymphocyte data and cytokine data were collected for the analysis. Overall survival (OS) was analyzed using Kaplan-Meier curves. Of 173 patients, 15 (8.7%) achieved pCR. A lower proportion of CD19+ B cells (7.5% vs. 10.4%, p = 0.008) was associated with pCR, and a high absolute count of NK cells was associated with better OS (p = 0.044).