Moran's index habitat and peritumoral radiomics based on digital breast tomosynthesis for predicting Ki-67 status in breast cancer

Background

The heterogeneity of breast cancer is a key factor influencing treatment decisions and patient prognosis. As a crucial cell proliferation marker, the expression level of the Ki-67 protein is closely associated with tumor aggressiveness, recurrence risk, and prognosis. The goal of this study was to develop and validate an integrated radiomics model based on digital breast tomosynthesis (DBT) that incorporates both habitat subregions and peritumoral features to preoperatively predict Ki-67 expression status in breast cancer.