The Japanese dental science review
Root canal microbiota in diabetic versus non-diabetic patients with apical periodontitis: A systematic review
By Aktemur Türker S and Uzunoğlu-Özyürek E.
Abstract
Background
This systematic review aimed to evaluate the differences in root canal microbiota composition and microbial load between diabetic and non-diabetic individuals with apical periodontitis.
Methods
Electronic searches were conducted in PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, the Cochrane Library and EBSCO up to 9 April 2026.Clinical studies using culture-dependent or molecular methods to identify microbial taxa in infected root canals of diabetic and non-diabetic individuals were included. Data on diabetes status, infection type, microbiological method, identified taxa, and quantitative microbial outcomes were extracted. Methodological quality was assessed using the Joanna Briggs Institute critical appraisal tool.
