Frontiers in cardiovascular medicine
Plasma trimethylamine N-oxide and arteriosclerotic cardiovascular disease: a systematic review and meta-analysis of case-control studies
By Ou Y, She J, Gao B and 6 others.
Abstract
Introduction
Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, has been implicated in atherosclerosis. However, the association between plasma TMAO levels and atherosclerotic cardiovascular disease (ASCVD) risk remains inconsistent across studies.
Methods
We searched PubMed, Embase, Cochrane, and Web of Science for case-control (including nested) studies reporting odds ratios (ORs) with 95% confidence intervals (CIs) for TMAO and ASCVD. Estimates were pooled under fixed- or random-effects assumptions according to the observed heterogeneity, supplemented by subgroup, sensitivity, and publication bias assessments.
