International neurourology journal
Exercise-Induced Activation of IGF-1/mTOR Signaling and Hippocampal BDNF/PGC-1α Expression Reverses Age-Related Motor Decline
By Kim T, Cho J, Kim Y and 2 others.
Abstract
Purpose
Aging is associated with a progressive decline in skeletal muscle function and motor coordination, contributing to reduced mobility and quality of life. While exercise is a well-established intervention to counteract age-related deterioration, the underlying molecular mechanisms in both muscle and the brain remain incompletely understood.
Methods
Young (4 months) and aged (20 months) male C57BL/6N mice were assigned to control or treadmill exercise groups. After 8 weeks of training, the grip strength, muscle histology, rotarod performance, and molecular markers related to muscle hypertrophy and brain plasticity were analyzed.
