Factors Associated With Knowledge of Sickle Cell Disease and Haemoglobin Genotype Awareness Among Pregnant Women in Three Health Centres in Libreville and Owendo, Gabon

Introduction

In Gabon, screening for sickle cell disease, a hereditary disorder that causes haemolytic anaemia due to the sickling of red blood cells, is systematic during pregnancy and mandatory before marriage. Several years after the implementation of these measures, this study aimed to identify the factors associated with knowledge of sickle cell disease and awareness of haemoglobin genotype among pregnant women. Patients and methods: This was a multicentre, cross-sectional, descriptive and analytical study conducted from May to December 2024 in three health centres in Greater Libreville. Pregnant women of any age, regardless of gestational age, who agreed to participate by giving written consent were included. Statistical analysis was performed using Epi-Info software, version 7.2.3.1. Multivariable logistic regression was additionally performed to identify independent determinants of haemoglobin genotype awareness and of general knowledge of sickle cell disease.