Association of Treatment Decentration with Early Outcomes Following SMILE Pro: A Secondary Analysis

Purpose

To evaluate the association of system-recorded treatment decentration with 3-month visual, refractive, and higher-order aberration (HOA) outcomes after SMILE Pro (VisuMax 800 femtosecond laser). Patients and methods: This secondary exploratory analysis of prospectively collected data included 186 eyes of 94 consecutive patients. Treatment decentration-the system-recorded scalar distance between the corneal vertex and the achieved lenticule center-was categorized as <0.10 mm (n = 94), 0.10-0.20 mm (n = 73), or ≥0.20 mm (n = 19). Primary outcomes were 3-month uncorrected distance visual acuity (UDVA), residual spherical equivalent (SE), and anterior corneal wavefront HOA (6-mm pupil) with its change from baseline (ΔHOA). Generalized estimating equations (GEE) clustered by patient constituted the primary analysis; rank-based tests were secondary.