Pre-admission prescription of selective serotonin reuptake inhibitors and mortality in critical illness: a national cohort study from 2020 to 2023

Background

We aimed to determine whether selective serotonin reuptake inhibitor (SSRI) prescription within 30 days before intensive care unit (ICU) admission was associated with 30-day and 90-day mortality in critically ill adults, and to evaluate effect modification by underlying psychiatric disorders.