Neuropsychiatric disease and treatment
Experimental Study on Anxiolytic and Antidepressant Effects of Zhi-Chi-Jie-Yu Granules in CUMS Mice and Prediction of Underlying Molecular Mechanisms
By Luo Y, Gao X, Shi W and 4 others.
Abstract
Objective
This study investigated the in‑vivo pharmacological effects of Zhi-Chi-Jie-Yu Granules(ZCK) on CUMS‑induced anxiety‑ and depression‑like behaviors in mice. Post‑hoc exploratory analyses including network pharmacology and molecular docking were further performed to generate potential mechanistic hypotheses for its anti‑depressant action.