Frontiers in immunology
Procoagulant effects of extracellular vesicles in patients with livedo reticularis
By Baniel A, Ricco C, Dhiman R and 10 others.
Abstract
Background
Extracellular vesicles (EVs) are lipid-delimited particles that mediate intercellular communication and have been implicated in both autoimmune and prothrombotic conditions. Livedo reticularis (LR) is a cutaneous vascular pattern associated with impaired dermal arteriolar blood flow and increased vascular risk, yet the contribution of EVs to LR pathogenesis has not been studied.
Objectives
To characterize the procoagulant properties, cellular origin, and proteomic profile of plasma-derived EVs in LR.
