Parkinson's disease
Peripheral HMGB1 Downregulation Is Associated With the S100-IL-17 Axis in Parkinson's Disease: An Integrated Bulk and Single-Cell Transcriptomic Analysis
By Wang S, Shi H, Meng X and 1 others.
Abstract
Background
Accumulating evidence implicates peripheral immune dysregulation in the pathogenesis of Parkinson's disease (PD). High-mobility group box 1 (HMGB1), a key alarmin released during mitochondrial stress, has been reported to be upregulated in the peripheral blood of PD patients, yet its precise role remains unclear.
