Vitamin B12 Alleviates Hepatic Ischemia-Reperfusion Injury with Restoration of Propanoate Metabolism and Mitochondrial Function

Background

Hepatic ischemia-reperfusion injury (HIRI) is a major cause of liver dysfunction after hepatectomy and liver transplantation and involves inflammatory, oxidative, mitochondrial, and metabolic disturbances. Although inflammatory and oxidative mechanisms have been extensively studied, metabolic alterations during HIRI remain less well characterized. This study investigated changes in propanoate metabolism during HIRI and evaluated the effects of vitamin B12 (VB12).