Neuropsychiatric disease and treatment
Associations Between Thalamic Gray Matter Volume and Psychomotor Symptoms in Major Depressive Disorder: A Voxel-Based Morphometry Study
By Gu Y, Wang X, Liu F and 6 others.
Abstract
Background
Major depressive disorder (MDD) is a heterogeneous disorder with diverse symptom profiles and treatment responses. Psychomotor retardation and agitation represent clinically relevant dimensions of MDD heterogeneity, but their neurobiological basis remains unclear. Given the role of the thalamus in motor regulation and affective processing, this study examined thalamic gray matter volume (GMV) differences among patients with MDD with predominant psychomotor retardation (MDD-R), patients with MDD with predominant psychomotor agitation (MDD-A), and healthy controls (HCs).