Frontiers in microbiology
Molecular epidemiology and mechanisms of Escherichia coli resistance to ertapenem but not other carbapenems in China
By Wang D, Yuan Y, Li W and 2 others.
Abstract
Purpose
To investigate the molecular epidemiology and resistance mechanisms of carbapenem-resistant Enterobacteriaceae (CRE) with a specific phenotype resistant to ertapenem, but susceptible to meropenem and imipenem.
Methods
Escherichia coli isolates (n = 424) were collected across the country; 54 isolates were CRE, of which 14 isolates were resistant to ertapenem but susceptible to meropenem and imipenem. Antimicrobial susceptibility testing were conducted using 17 drugs on the 14 isolates. Whole-genome sequencing (WGS) was used to analyze the isolates' drug resistance genes carried, plasmid types, virulence genes, and drug resistance homology. Furthermore, efflux pumps and outer membrane proteins were analyzed.
