Infection and drug resistance
Risk Factors and Medical Burden of Multidrug-Resistant Organism Infection in Hospitalized Patients with Pneumonia
By Dai J, Xing Y, Zhong J and 6 others.
Abstract
Introduction
Multi-drug resistant organism (MDRO) infections represent a global public health challenge. Patients hospitalized with pneumonia are prone to secondary MDRO infections, which can lead to poor prognosis, significantly prolong hospital stays, and increase medical and economic burdens.
Methods
This single‑center retrospective cohort study conducted at a tertiary hospital in Shanghai, China aimed to identify risk factors for MDRO infection and assess its hospitalization‑related burden, and to construct a predictive nomogram. A total of 1686 patients with pneumonia were enrolled. The data were analyzed through 1:2 manual matching. Logistic regression was used to screen independent risk factors for multidrug‑resistant organism (MDRO) infections; Generalized Linear Models (GLMs) were employed to quantify the increase in hospital stay and medical expenses caused by MDROs. A predictive nomogram was constructed and validated using ROC curves and calibration curves.
