Immunity, inflammation and disease
Cell-Type-Specific HSPA1B Expression Links COPD and Atherosclerosis
By Zhao Y, Cao F, Zhang H and 2 others.
Abstract
Background
Chronic obstructive pulmonary disease (COPD) and atherosclerosis frequently coexist, but their shared immune mechanisms remain incompletely understood.
Methods
We integrated single-cell RNA-sequencing datasets from COPD lungs and atherosclerotic lesions to characterize immune-cell composition, intercellular communication, and overlapping upregulated genes. Cell-type-specific sc-eQTL data from oneK1K were further combined with FinnGen GWAS summary statistics for COPD and coronary atherosclerosis using Mendelian randomization.
