Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Vespula spp. venom immunotherapy: basophil excitability and FcεRI/FcγRIIb expression
By Fleissner J, Stoevesandt J, Goebeler M and 2 others.
Abstract
Background
Basophils are recognized as important effector cells during the sensitization and effector phases of IgE-mediated allergy. Besides histamine release during anaphylaxis, basophils contribute to early immune polarization as an important source of Th2-associated cytokines. Vespula spp. venom immunotherapy (VIT) represents a prime example of clinically highly effective allergen-specific immunotherapy. This study investigated functional and phenotypic changes in circulating basophils during early VIT in a homogenous case series.
