International journal of general medicine
Prognostic Value of Systemic Inflammatory Indices in Hospitalized Patients with HFrEF: A Multicenter Retrospective Cohort Study
By Qiu Z, Cui P, Cai X and 2 others.
Abstract
Objective
This study sought to examine the associations between four inflammatory biomarkers and 1-year adverse cardiovascular outcomes among hospitalized patients with heart failure with reduced ejection fraction (HFrEF) and to compare their prognostic performance.
Methods
A multicenter retrospective cohort study was conducted involving 1814 hospitalized patients with HFrEF (LVEF <40%). Four inflammation-derived biomarkers were derived from standard blood test results. The relationships between these biomarkers and the 1-year incidence of adverse cardiovascular outcomes were analyzed using Cox proportional hazards regression and restricted cubic spline (RCS) modeling. Event-free survival across biomarker tertiles was compared via Kaplan-Meier survival analysis. The discriminative ability of each biomarker was assessed through receiver operating characteristic (ROC) curves, time-dependent ROC analyses, and C-statistics. Additional sensitivity analyses were performed to verify the stability and reliability of the results.
