Neuropsychiatric disease and treatment
Risk-Stratified Tiered Intervention Among Chinese Clinical High-Risk for Psychosis Patients and Attenuated Negative Symptoms as a Predictor of 1-Year Psychosis Conversion: A Retrospective Propensity-Matched Real-World Cohort Study
By Zhang J, Deng J, Tu X and 1 others.
Abstract
Objective
This retrospective propensity-score-matched real-world cohort study aimed to evaluate the clinical efficacy of risk stratification combined with tiered intervention in young Chinese patients at clinical high-risk (CHR) for psychosis, and to explore whether attenuated negative symptoms could independently predict 1-year conversion to overt psychosis.
Methods
A total of 150 CHR patients receiving risk-stratified tiered management were enrolled as the intervention group, and 75 CHR patients receiving conventional routine care were matched as the control group via propensity-score matching (PSM). All participants completed standardized two-stage clinical screening, cranial MRI to exclude organic brain lesions, and systematic symptom and functional assessments. Logistic regression and receiver-operating-characteristic (ROC) curve analyses were performed to identify independent predictors of psychosis conversion, with a specific focus on attenuated negative symptoms. Primary outcomes included 1-year psychosis conversion rate, changes in global functioning, and treatment adherence.
