Drug design, development and therapy
Honokiol Alleviates Dry Eye-Related Corneal Epithelial Damage by Activating SIRT3/PINK1-Mediated Mitophagy
By Huang Y, Cao X, Yan X and 7 others.
Abstract
Background
Dry eye is a common ocular surface disease characterized by corneal epithelial damage, yet effective therapies targeting mitochondrial dysfunction remain limited.
Purpose
To investigate the protective effects of honokiol (HKL) against dry eye-related corneal epithelial injury and elucidate the underlying mechanisms focusing on SIRT3 and PINK1-mediated mitophagy.
