Global heart
Sleep Phenotype, Shift-Related Occupation, and Coronary Plaque Complexity in Young Adults: Association with CT-Derived Functional Ischemia
By Chen Y, Zhao Q, Gao J and 2 others.
Abstract
Background
Sleep disruption and irregular work schedules are increasingly recognized as behavioral risk factors for premature cardiovascular disease. Their associations with coronary plaque complexity and CT-derived functional ischemia in young adults remain underexplored.
Objective
To investigate the association of multidimensional sleep phenotype, shift-related occupation, and coronary plaque complexity as well as CT-derived functional ischemia in adults aged ≤40 years, adjusting for clinical confounders.
Methods
This retrospective study included 3,983 young adults who underwent coronary CT angiography (CCTA). Sleep phenotype was assessed using a multidimensional score incorporating sleep duration, timing, regularity, quality, and sleep-related symptoms. Occupations were classified as shift-related or non-shift. Coronary plaque characteristics, including stenosis severity, minimum lumen area, lesion length, diffuse disease, occlusion, coronary artery calcium score, and CT-derived fractional flow reserve (CT-FFR), were analyzed. Multivariable logistic regression, adjusted for age, sex, BMI, smoking, hypertension, diabetes, dyslipidemia, and shift-related occupation, assessed associations with CT-FFR ≤ 0.80.
