Psoriasis
Causal Relationship Between Psoriatic Arthritis and Coronary Heart Disease: A Mendelian Randomization and Bioinformatics Analysis
By Yin X, Zhao S, Huang W and 5 others.
Abstract
Objective
Psoriatic arthritis (PsA) often coexists with coronary heart disease (CHD). We integrated Mendelian randomization (MR), bioinformatics and reverse network pharmacology to dissect their causality, biomarkers, candidate therapeutics and transcription factors (TFs).
Methods
With PsA and CHD GWAS statistics, five MR methods including inverse variance weighted (IVW), weighted mode, weighted median, simple mode, MR Egger were used to assess causality, followed by sensitivity analyses. We analyzed the differentially expressed genes (DEGs) from the PsA and CHD GEO datasets and identified co-DEGs through intersection. GO, KEGG and GeneMANIA analyses elucidated their functions and pathways. We screened therapeutic candidates through DSigDB and reverse network pharmacology, and mined co-DEGs-related TFs from TRRUST.
