BMC cardiovascular disorders
Native myocardial T1 mapping using rapid 1.5T T1FLASH and T1 MOLLI during breath-hold and free-breathing
By Röwer LM, Hussen-Demir Y, Verde PE and 5 others.
Abstract
Background
Quantitative myocardial T1 mapping is an established technique in cardiovascular magnetic resonance (CMR). However, conventional T1 mapping requires relatively long breath-holds (BH), which may lead to breathing artifacts and reduced image quality in patients with limited BH capacity. The T1 fast low angle shot (T1FLASH) sequence enables myocardial T1 mapping with shorter BH durations.
Methods
In this prospective study, 14 healthy adult volunteers (8 female; mean age 27 ± 4 years) underwent myocardial T1 mapping at 1.5 T using modified Look-Locker inversion recovery with motion correction (T1 MOLLI MOCO) and rapid T1FLASH. Both sequences were acquired during BH and free breathing (FB). Global and segmental myocardial T1 values and image quality were assessed. Interrater, intrarater, and interstudy reproducibility were evaluated. Comfort was assessed using a questionnaire. Statistical analysis included the Shapiro-Wilk test, paired t-test, Pearson correlation, Bland-Altman analysis, intraclass correlation coefficient, Wilcoxon signed-rank test, and Spearman rank correlation (p < 0.05).
