International journal of women's health
Combined Assessment of EZH2 and EGFR as Potential Diagnostic Biomarkers for Epithelial Ovarian Tumors: Bioinformatics Analysis and Clinical Validation
By Wang X, Ma Y and Lu H.
Abstract
Purpose
This study was to investigate the expression and clinical significance of Enhancer of Zeste Homolog 2 (EZH2) and Epidermal Growth Factor Receptor (EGFR) in epithelial ovarian cancer (EOC).
Methods
EZH2 and EGFR in EOC were analysed by bioinformatics. Samples from 55 patients with epithelial ovarian tumors (22 malignant, 14 borderline, and 19 benign) and 10 normal ovarian tissue were collected, EZH2 and EGFR expression levels were measured by immunohistochemistry (IHC) and Enzyme-Linked Immunosorbent Assay (ELISA).