Association and Mechanistic Insights Linking Bisphenol A to Psoriasis: Integrative Analysis of Bulk Transcriptomics, Network Toxicology, Mendelian Randomization and Single‑cell RNA Sequencing

Purpose

Psoriasis is a chronic immune-mediated skin disease with complex etiology, and environmental factors such as bisphenol A (BPA) exposure are suspected pathogenic factors. This study aimed to identify potential diagnostic biomarkers linking BPA exposure to psoriasis and to explore the latent interaction and mechanisms between BPA and candidate biomarkers. Patients and methods: Psoriasis-related transcriptomic datasets (GSE14905, GSE13355, GSE183047) were downloaded from the Gene Expression Omnibus (GEO) database, and psoriasis-related genome-wide association study (GWAS) data were obtained from the GWAS Catalog. Target genes of psoriasis and BPA were retrieved from multiple public databases. A multi-omics integrative strategy was adopted in this study, combining bulk transcriptomics, network toxicology, Mendelian randomization, and single-cell RNA sequencing (scRNA-seq). Computational molecular binding prediction and in vivo animal experiments were further performed for biomarker validation.