Health science reports
The Effect of N-Acetyl Cysteine on Serum Lipid Profile and Heavy Metals in Women With Endometriosis Undergoing ICSI: A Randomized Controlled Trial
By Khorasani F, Mirabi P and Esmaeilzadeh S.
Abstract
Background and aims: Endometriosis is associated with oxidative stress and heavy metal accumulation. This study evaluated whether N-acetylcysteine (NAC) reduces serum heavy metals and improves lipid profiles in women with endometriosis undergoing fertility treatment.
Methods
In this randomized controlled trial, 60 women with laparoscopy-confirmed endometriosis were allocated to NAC (1.8-3 g/day, increased to 3 g/day in participants with BMI ≥ 25 kg/m) or control groups for 6 weeks. Serum levels of lead, cadmium, nickel, chromium, and lipid profiles were measured using atomic absorption spectroscopy and enzymatic assays. Primary outcomes were heavy metal changes; secondary outcomes were lipid profile alterations.
