Research and practice in thrombosis and haemostasis
The effect of F8 missense variants on desmopressin response in people with nonsevere hemophilia A investigated using machine learning
By Cloesmeijer ME, Del Castillo Alferez J, Janssen A and 7 others.
Abstract
Background
Interindividual variability in factor FVIII peak levels after desmopressin administration in people with nonsevere hemophilia A underscores the need for individual testing before clinical application. The FVIII gene (F8) variant is a strong determinant of the desmopressin response.
Objectives
To investigate the effect of F8 missense variants on FVIII peak levels in response to desmopressin.
