Schizophrenia research. Cognition
Clinical insight in schizophrenia: Time-specific associations with symptoms, cognition and antipsychotic mechanisms
By Stabell LA, Johnsen E, Kroken RA and 5 others.
Abstract
Background
Impaired clinical insight in schizophrenia is associated with poor treatment adherence and outcomes. Previous research on the influence of symptoms, cognition, and antipsychotic exposure has been inconclusive and restricted to multi-episode samples. We examined time-specific associations between overall psychopathology, cognitive functioning, antipsychotic D₂ receptor mechanisms, antipsychotic exposure and dosage, and insight, whether these associations changed over time, and whether dosage moderated them.
